The University of Guanajuato, Mexico has experimented with innovative learning practices in sustainable development. They have developed a Social Laboratory of Interpretive Audio-visual Ethnography to encourage sustainability literacy and engagement amongst undergraduate and postgraduate students. The laboratory works on a broad mandate of addressing sustainability, mega-diversity, social responsibility, autonomy, technology, collaboration and interdisciplinarity. Via a network of practice communities, students develop, explore and test sustainable social innovations and Ecotechnologies in a framework of practice- and problem-based learning, with a focus on presenting inclusive dialogues from an array of social actors. Students are then trained and encouraged to translate results in audio-visual formats. Awareness and fostering of indigenous values is also encouraged, for example via the laboratory’s Sacred Medicine project.